Large-volume low apparent diffusion coefficient lesions predict poor survival in bevacizumab-treated glioblastoma patients
نویسندگان
چکیده
منابع مشابه
Apparent diffusion coefficient histogram analysis stratifies progression-free survival in newly diagnosed bevacizumab-treated glioblastoma.
BACKGROUND AND PURPOSE Currently it is difficult to predict tumor response to anti-angiogenic therapy in individual patients. Our aim was to determine if ADC histogram analysis can stratify progression-free and overall survival in patients with newly diagnosed GBM treated "up-front" (ie, before tumor recurrence) with bevacizumab. MATERIALS AND METHODS Up-front bevacizumab-treated and control ...
متن کاملGraded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab.
Diffusion imaging has shown promise as a predictive and prognostic biomarker in glioma. We assessed the ability of graded functional diffusion maps (fDMs) and apparent diffusion coefficient (ADC) characteristics to predict overall survival (OS) in recurrent glioblastoma multiforme (GBM) patients treated with bevacizumab. Seventy-seven patients with recurrent GBMs were retrospectively examined. ...
متن کاملGraded functional diffusion maps (fDMs) predict survival in recurrent glioblastoma treated with bevacizumab
Introduction The functional diffusion map (fDM) was developed in order to examine localized ADC changes by calculating voxel-wise changes in ADC (ΔADC) measured in the same patient over time . This technique has demonstrated utility in predicting the effect of cytotoxic chemotherapy and radiotherapy within the contrast-enhancing tumor bed as well as within regions of abnormal fluid-attenuated i...
متن کاملDifferentiation of benign and malignant breast lesions by apparent diffusion coefficient value in mass and non-mass lesions
Background: Diffusion-weighted imaging (DWI) is one of methods in evaluation of breast lesions. We aimed to investigate the apparent diffusion coefficient (ADC) values in breast tumors and their accuracy in differentiating benign versus malignant lesions. Methods: In this cross-sectional study, 72 patients with 88 breast lesions were investigated by 1.5-T breast MRI from 2015 to 2017 in Athari...
متن کاملApparent Diffusion Coefficient Measures on MR Correlate with Survival in Glioblastoma Multiforme
Introduction: Malignant gliomas are currently evaluated by subjective assessment of T2and contrast-enhanced T1-weighted imaging. Glioblastoma multiforme (GBM) is largely considered a single clinical entity for the purposes of treatment rationalisation, although genetic biomarkers which predict response to treatment in glioma from biopsy samples have been discovered. Non-invasive imaging biomark...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2015
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/nov268